Preferred Label : Alisertib Sodium;
NCIt synonyms : MLN8237-004; MLN8237 Sodium;
NCIt definition : The sodium salt form of alisertib, a second-generation, orally bioavailable, selective
inhibitor of the serine/threonine protein kinase Aurora A kinase, with potential antineoplastic
activity. Upon oral administration, alisertib targets, binds to and inhibits Aurora
A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus,
disruption of chromosome segregation, and inhibition of cell proliferation in susceptible
cancer cells. Aurora A kinase localizes to the spindle poles and to spindle microtubules
during mitosis, and is thought to regulate spindle assembly. Aberrant expression of
Aurora kinases occurs in a wide variety of cancers and plays a key role in cancer
cell proliferation.;
UNII : T76P158V9D;
InChIKey : WLPXWQKMVACWII-UHFFFAOYSA-M;
CAS number : 1208255-63-3;
NCI Metathesaurus CUI : CL541357;
Origin ID : C142912;
UMLS CUI : C4684905;
Semantic type(s)
- chemical_or_drug_affects_gene_product
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
