" /> Alisertib - CISMeF





Preferred Label : Alisertib;

NCIt synonyms : Aurora A Kinase Inhibitor MLN8237; Benzoic Acid, 4-((9-Chloro-7-(2-Fluoro-6-Methoxyphenyl)-5H-Pyrimido(5,4-d)(2)Benzazepin-2-yl)Amino)-2-Methoxy-;

NCIt definition : A second-generation, orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity. Alisertib binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation. Aurora A kinase localizes to the spindle poles and to spindle microtubules during mitosis, and is thought to regulate spindle assembly. Aberrant expression of Aurora kinases occurs in a wide variety of cancers, including colon and breast cancers.;

UNII : T66ES73M18;

InChIKey : ZLHFILGSQDJULK-UHFFFAOYSA-N;

CAS number : 1028486-01-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1028486-01-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : MLN-8237;

Chemical formula : C27H20ClFN4O4;

Codes from synonyms : 19;

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12/05/2024


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