Preferred Label : Aurora A Kinase Inhibitor VIC-1911;
NCIt synonyms : Aurora A Kinase Inhibitor TAS-119;
NCIt definition : An orally bioavailable inhibitor of the serine/threonine protein kinase aurora A,
with potential antimitotic and antineoplastic activities. Upon intravenous administration,
aurora A kinase inhibitor VIC-1911 binds to and inhibits aurora A kinase, which may
result in disruption of the assembly of the mitotic spindle apparatus, disruption
of chromosome segregation, inhibition of cell division and the induction of apoptosis
in cells overexpressing aurora A kinase. Aurora A kinase localizes to the spindle
poles and to spindle microtubules during mitosis; it plays an essential role in the
regulation of spindle assembly. Aurora kinase A is overexpressed in a wide variety
of cancers.;
Molecule name : TAS-2104; TAS-119; VIC 1911; VIC-1911;
NCI Metathesaurus CUI : CL473487;
Origin ID : C116068;
UMLS CUI : C5666845;
Semantic type(s)
- chemical_or_drug_affects_gene_product
- concept_is_in_subset
