Preferred Label : Ilorasertib;
NCIt synonyms : 1-(4-(4-Amino-7-(1-(2-hydroxyethyl)-1H-pyrazol-4-yl)thieno[3,2-c]pyridin-3-yl)phenyl)-3-(3-fluorophenyl)urea;
NCIt definition : An orally bioavailable, adenosine triphospate mimetic, and inhibitor of Aurora kinases,
vascular endothelial growth factor receptors (VEGFRs) and platelet-derived growth
factor receptor (PDGFRs), with potential antineoplastic activity. Upon administration,
ilorasertib selectively binds to and inhibits Aurora kinases A, B and C, which may
disrupt both the assembly of the mitotic spindle apparatus and chromosome segregation,
and inhibit both cellular division and proliferation in Aurora kinase-overexpressing
tumor cells. In addition, ilorasertib selectively binds to and inhibits VEGFRs and
PDGFRs, which may result in the inhibition of both angiogenesis and tumor cell proliferation
in VEGFR/PDGFR-overexpressing tumor cells. This agent also inhibits the Src family
of cytoplasmic tyrosine kinases. Aurora kinases A, B and C, are serine/threonine kinases
that play essential roles in mitotic checkpoint control and are overexpressed by a
wide variety of tumor cell types. Both VEGFRs and PDGFRs are receptor tyrosine kinase
families whose members may be upregulated in various tumor cell types.;
UNII : 6L5D03D975;
InChIKey : WPHKIQPVPYJNAX-UHFFFAOYSA-N;
CAS number : 1227939-82-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1227939-82-3
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : A-968660.0; ABT-348;
Origin ID : C116729;
UMLS CUI : C3660880;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
