" /> Aurora A Kinase Inhibitor LY3295668 Erbumine - CISMeF





Preferred Label : Aurora A Kinase Inhibitor LY3295668 Erbumine;

NCIt synonyms : AK-01 Erbumine; Aurora Kinase A Inhibitor LY3295668 Erbumine; LY-3295668 Erbumine; LY3295668 Erbumine; LY 3295668 Erbumine;

NCIt definition : The tert-butylamine salt form of LY3295668, an orally bioavailable inhibitor of the serine/threonine protein kinase aurora A, with potential antimitotic and antineoplastic activities. Upon administration, aurora A kinase inhibitor LY3295668 targets, binds to and inhibits the activity of aurora A kinase. This may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, inhibition of cell division and the induction of apoptosis in cells overexpressing aurora A kinase. Aurora A kinase, overexpressed in a wide variety of cancers, plays an essential role in the regulation of spindle assembly and mitosis.;

NCI Metathesaurus CUI : CL978388;

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15/05/2024


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