Polo-like Kinase 1 Inhibitor GSK461364

Preferred Label : Polo-like Kinase 1 Inhibitor GSK461364;

NCIt related terms : GSK-461364;

NCIt definition : A small molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor GSK461364 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner.;

UNII : 8QO27TK6Q4;

CAS number : 929095-18-1;

Molecule name : GSK461364;

Details

Origin ID

C70948;

UMLS CUI

C2347618;

Currated CISMeF NLP mapping
- GSK 461364 [MeSH concept]
- GSK 461364 [MeSH Supplementary Concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- GSK 461364 [MeSH Supplementary Concept]
- GSK 461364 [MeSH concept]
chemical_or_drug_affects_gene_product
- Serine/Threonine-Protein Kinase PLK1 [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Enzyme Inhibition [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Aurora Kinase A [NCIt concept]

Keyword's position in hierarchy(ies) :

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