NCIt definition : A small molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic
activity. Polo-like kinase 1 inhibitor GSK461364 selectively inhibits Plk1, inducing
selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing
reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1,
named after the polo gene of Drosophila melanogaster, is a serine/threonine protein
kinase involved in regulating mitotic spindle function in a non-ATP competitive manner.;
UNII : 8QO27TK6Q4;
CAS number : 929095-18-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 929095-18-1
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;