Aurora Kinase Inhibitor AMG 900

Preferred Label : Aurora Kinase Inhibitor AMG 900;

NCIt synonyms : N-(4-(3-(2-Aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine;

NCIt related terms : AMG-900;

NCIt definition : A small-molecule inhibitor of Aurora kinases A, B and C with potential antineoplastic activity. Aurora kinase inhibitor AMG 900 selectively binds to and inhibits the activities of Aurora kinases A, B and C, which may result in inhibition of cellular division and proliferation in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis and are overexpressed by a wide variety of cancer cell types.;

UNII : 9R2G075611;

CAS number : 945595-80-2;

Molecule name : AMG 900;

Details

Origin ID

C82349;

UMLS CUI

C2826111;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Aurora Kinase A [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Enzyme Inhibition [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Aurora Kinase A [NCIt concept]
- Aurora Kinase B [NCIt concept]
- Aurora Kinase C [NCIt concept]

Keyword's position in hierarchy(ies) :

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