Aurora Kinase Inhibitor MLN8054

Preferred Label : Aurora Kinase Inhibitor MLN8054;

NCIt synonyms : Benzoic Acid, 4-((9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido(5,4-d)(2)benzazepin-2-yl)amino)-;

NCIt related terms : MLN8054;

NCIt definition : An orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity. Auora kinase inhibitor MLN8054 binds to and inhibits Aurora kinase A, resulting in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation. Aurora A localizes in mitosis to the spindle poles and to spindle microtubules and is thought to regulate spindle assembly. Aberrant expression of Aurora kinases occurs in a wide variety of cancers, including colon and breast cancers.;

UNII : BX854EHD63;

InChIKey : HHFBDROWDBDFBR-UHFFFAOYSA-N;

CAS number : 869363-13-3;

Molecule name : MLN 8054; MLN-8054;

Details

Origin ID

C61075;

UMLS CUI

C1831780;

CISMeF manual mappings
- MLN8054 [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- MLN8054 [MeSH concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MLN8054 [MeSH Supplementary Concept]
- MLN8054 [MeSH concept]
chemical_or_drug_affects_gene_product
- Aurora Kinase A [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Aurora Kinase A [NCIt concept]

Keyword's position in hierarchy(ies) :

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