NCIt definition : An orally available small molecule inhibitor of Aurora kinases (AKs) A and B, Janus
kinases (JAKs), fibroblast growth factor receptors (FGFRs) and vascular endothelial
growth factor receptors (VEGFRs), with potential antineoplastic and immunomodulatory
activities. Upon oral administration, tinengotinib selectively binds to and inhibits
AKs A and B, which inhibit cell division in tumor cells that overexpress AKs. Tinengotinib
also targets JAKs that are involved in cytokine signaling and inflammation, and FGFRs
and VEGFRs, which are overexpressed in the microenvironment (TME) and contribute to
neovascularization, tumor growth and metastasis. These kinases are overexpressed by
a wide variety of cancer cell types and drive tumor cell proliferation.;