Fibroblast Growth Factor Receptor Family

Preferred Label : Fibroblast Growth Factor Receptor Family;

NCIt synonyms : FGF Receptor; FGF-R; FGFR; FGF Receptor Family; FGFR Family Protein; FGFR Family;

NCIt definition : Family of receptor tyrosine kinases for fibroblast growth factor. Amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution.;

Details

Origin ID

C17297;

UMLS CUI

C0060369;

Automatic exact mappings (from CISMeF team)
- Fibroblast growth factor receptor 2 [OMIM gene]
- fibroblast growth factor-activated receptor activity [GO term]
- receptors, fibroblast growth factor [MeSH concept]
- receptors, fibroblast growth factor [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- receptors, fibroblast growth factor [MeSH concept]
- receptors, fibroblast growth factor [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Fibroblast Growth Factor Receptor Family Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Orantinib [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Growth Factor Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Alofanib [NCIt concept]
- Aurora B/VEGFR/FGFR Inhibitor AL8326 [NCIt concept]
- Derazantinib [NCIt concept]
- Erdafitinib [NCIt concept]
- FGF Receptor Antagonist HGS1036 [NCIt concept]
- FGFR Inhibitor [NCIt concept]
- FGFR Inhibitor ASP5878 [NCIt concept]
- FGFR Inhibitor CPL304110 [NCIt concept]
- FGFR Inhibitor ET0111 [NCIt concept]
- FGFR/VEGFR/PDGFR/FLT3/SRC Inhibitor XL999 [NCIt concept]
- FGFR1/2/3 Inhibitor HMPL-453 [NCIt concept]
- FGFR4 Inhibitor ICP-105 [NCIt concept]
- Fexagratinib [NCIt concept]
- Futibatinib [NCIt concept]
- Nefextinib [NCIt concept]
- Nintedanib [NCIt concept]
- Nintedanib Esylate [NCIt concept]
- Pan-FGFR Inhibitor ABSK-121 [NCIt concept]
- Pan-FGFR Inhibitor LY2874455 [NCIt concept]
- Pemigatinib [NCIt concept]
- Ponatinib Hydrochloride [NCIt concept]
- Segigratinib [NCIt concept]
- Tinengotinib [NCIt concept]
- Zoligratinib [NCIt concept]
- pan FGFR Inhibitor PRN1371 [NCIt concept]

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