Preferred Label : Fanregratinib;
NCIt synonyms : FGFR Inhibitor HMPL-453; FGFR1/2/3 Inhibitor HMPL-453;
NCIt definition : An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) types
1, 2, and 3 (FGFR1/2/3), with potential antineoplastic activity. Upon administration,
fanregratinib binds to and inhibits FGFR1/2/3, which may result in the inhibition
of FGFR1/2/3-related signal transduction pathways. This inhibits proliferation in
FGFR1/2/3-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases
(RTKs) upregulated in many tumor cell types, plays a key role in cellular proliferation,
migration and survival.;
UNII : 8RWL2B2CLS;
CAS number : 1628537-44-9;
Molecule name : HMPL 453; HMPL-453;
NCI Metathesaurus CUI : CL552165;
Origin ID : C150383;
UMLS CUI : C4725693;
Semantic type(s)
- concept_is_in_subset
- has_target
