Preferred Label : FGFR4 Inhibitor ICP-105;
NCIt synonyms : FGFR4 Antagonist ICP-105;
NCIt definition : An orally bioavailable inhibitor of human fibroblast growth factor receptor 4 (FGFR4),
with potential antineoplastic activity. Upon oral administration, ICP-105 specifically
targets, binds to and blocks the binding of the ligand FGF19 to FGFR4. This prevents
the activation of FGFR4, inhibits FGFR4-mediated signaling and leads to an inhibition
of tumor cell proliferation in FGFR4-overexpressing cells. FGFR4, a receptor tyrosine
kinase overexpressed on a variety of cancer cell types, is involved in tumor cell
proliferation, differentiation, angiogenesis, and survival. FGF19 is overexpressed
by certain tumor cell types.;
Molecule name : ICP-105; ICP 105;
NCI Metathesaurus CUI : CL973353;
Origin ID : C162852;
UMLS CUI : C5206844;
Semantic type(s)
- concept_is_in_subset
- has_target
