Preferred Label : Zoligratinib;
NCIt synonyms : Debiopharm 1347; FGFR Inhibitor Debio 1347;
NCIt definition : An orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes
1 (FGFR-1), 2 (FGFR-2) and 3 (FGFR-3), with potential antineoplastic activity. Zoligratinib
binds to and inhibits FGFR-1, -2, and -3, which result in the inhibition of FGFR-mediated
signal transduction pathways. This leads to the inhibition of both tumor cell proliferation
and angiogenesis, and causes cell death in FGFR-overexpressing tumor cells. FGFR,
a family of receptor tyrosine kinases upregulated in many tumor cell types, is essential
for tumor cellular proliferation, differentiation and survival.;
UNII : NR9ZYH80Z8;
InChIKey : BEMNJULZEQTDJY-UHFFFAOYSA-N;
CAS number : 1265229-25-1;
Molecule name : Debio-1347; debio 1347; debio 1347-101; CH5183284; FF284;
NCI Metathesaurus CUI : CL1412276;
Origin ID : C174762;
UMLS CUI : C5420941;
Semantic type(s)
- concept_is_in_subset
- has_target
