Fibroblast Growth Factor Receptor 2

Preferred Label : Fibroblast Growth Factor Receptor 2;

NCIt synonyms : FGFR-2; KGF Receptor; Keratinocyte Growth Factor Receptor; KGFR; FGFR2; FGFR2(IIIc); Fibroblast Growth Factor Receptor 2 Isoform IIIc; FGFR2-IIIc; K-sam; Fibroblast Growth Factor Receptor-2; FGFR2 IIIc; EC 2.7.10.1; FGFR-2 IIIc; BEK; FGFR2IIIc; CD332 Antigen;

CISMeF acronym : KGFR; BEK; FGFR2;

NCIt definition : Fibroblast growth factor receptor 2 (821 aa, 92 kDa) is encoded by the human FGFR2 gene. This protein plays a role in heparin-dependent fibroblast growth factor signaling.;

NCIt note : At least 23 isoforms of the fibroblast growth factor receptor 2 protein have been described. They are the products of alternative splicing and exibihit tissue-specific patterns of expression.; UniProt has designated this isoform of fibroblast growth factor receptor 2, where alternative splicing leads the expression of the IIIc exon encoding the second half of the third immunoglobulin-like domain located in the extracellular domain of this receptor, as the canonical form. This isoform is expressed in mesenchymal lineage cells and has differential ligand binding activity when compared to the IIIa and IIIb forms.;

Details

Origin ID

C17411;

UMLS CUI

C1259992;

Currated CISMeF NLP mapping
- keratinocyte growth factor receptor [MeSH concept]
- keratinocyte growth factor receptor [MeSH Supplementary Concept]
OMIM relation
- Fibroblast growth factor receptor 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- FGFR2 protein, human [MeSH concept]
- FGFR2 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- FGFR2 Gene [NCIt concept]
- Fibroblast Growth Factor Receptor Family Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Bone Tissue [NCIt concept]
- Cartilaginous Tissue [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Growth Factor Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_gene_product_variant
- FGFR2 NP_000132.3:p.C382R [NCIt concept]
- FGFR2 NP_000132.3:p.K659E [NCIt concept]
- FGFR2 NP_000132.3:p.N549H [NCIt concept]
- FGFR2 NP_000132.3:p.N549K [NCIt concept]
- FGFR2 NP_000132.3:p.P253R [NCIt concept]
- FGFR2 NP_000132.3:p.S252W [NCIt concept]
- FGFR2 NP_000132.3:p.S372C [NCIt concept]
- FGFR2 NP_000132.3:p.V679F [NCIt concept]
- FGFR2 NP_000132.3:p.Y375C [NCIt concept]
- FGFR2 Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- FGF Signaling Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Epithelial Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Organogenesis [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Apitolisib [NCIt concept]
- Aprutumab Ixadotin [NCIt concept]
- FGFR1/2/3 Inhibitor TYRA-200 [NCIt concept]
- Gunagratinib [NCIt concept]
- Infigratinib [NCIt concept]
- Infigratinib Phosphate [NCIt concept]
- Lirafugratinib [NCIt concept]
- Lirafugratinib Hydrochloride [NCIt concept]
- Receptor Tyrosine Kinase Inhibitor R1530 [NCIt concept]
- Resigratinib [NCIt concept]
- Rogaratinib [NCIt concept]

Keyword's position in hierarchy(ies) :

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