Rogaratinib - CISMeF

Preferred Label : Rogaratinib;

NCIt synonyms : 4-((4-Amino-6-(methoxymethyl)-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo(2,1-f)(1,2,4)triazin-7-yl)methyl)piperazin-2-one;

NCIt definition : A pan inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities. Rogaratinib inhibits the activities of FGFRs, which may result in the inhibition of both tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. FGFRs are a family of receptor tyrosine kinases, which may be upregulated in various tumor cell types and may be involved in tumor cell differentiation and proliferation, tumor angiogenesis, and tumor cell survival.;

UNII : 98BSN6N516;

InChIKey : HNLRRJSKGXOYNO-UHFFFAOYSA-N;

CAS number : 1443530-05-9;

Molecule name : BAY-1163877;

NCI Metathesaurus CUI : CL454405;

Details

Origin ID

C112205;

UMLS CUI

C5139822;

Currated CISMeF NLP mapping
- Rogaratinib [MeSH concept]
- Rogaratinib [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Rogaratinib [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Fibroblast Growth Factor Receptor 1 [NCIt concept]
- Fibroblast Growth Factor Receptor 2 [NCIt concept]
- Fibroblast Growth Factor Receptor 3 [NCIt concept]
- Fibroblast Growth Factor Receptor 4 [NCIt concept]

Keyword's position in hierarchy(ies) :

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