Fibroblast Growth Factor Receptor 3

Preferred Label : Fibroblast Growth Factor Receptor 3;

NCIt synonyms : EC 2.7.1.112; FGFR3; Tyrosine Kinase JTK4; Hydroxyaryl-Protein Kinase; CD333 Antigen; Fibroblast Growth Factor Receptor-3; EC 2.7.10.1; FGFR-3;

NCIt definition : Fibroblast growth factor receptor 3 (806 aa, 88 kDa) is encoded by the human FGFR3 gene. This protein is involved in fibroblast growth factor signaling and skeletal development.;

Details

Origin ID

C26129;

UMLS CUI

C0527057;

OMIM relation
- Fibroblast growth factor receptor 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- FGFR3 protein, human [MeSH concept]
- FGFR3 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- FGFR3 Gene [NCIt concept]
- Fibroblast Growth Factor Receptor Family Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Growth Factor Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_gene_product_variant
- FGFR3 NP_000133.1:p.G370C [NCIt concept]
- FGFR3 NP_000133.1:p.G380R [NCIt concept]
- FGFR3 NP_000133.1:p.K650E [NCIt concept]
- FGFR3 NP_000133.1:p.R248C [NCIt concept]
- FGFR3 NP_000133.1:p.S249C [NCIt concept]
- FGFR3 NP_000133.1:p.S371C [NCIt concept]
- FGFR3 NP_000133.1:p.Y373C [NCIt concept]
- FGFR3 Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Bladder Cancer Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- FGF Signaling Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Skeletal Development [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Actinium Ac 225 Vofatamab [NCIt concept]
- Anti-FGFR3 Antibody-drug Conjugate LY3076226 [NCIt concept]
- Dovitinib [NCIt concept]
- Dovitinib Lactate [NCIt concept]
- Dovitinib Lactate Anhydrous [NCIt concept]
- FGFR1/2/3 Inhibitor TYRA-200 [NCIt concept]
- FGFR3 Inhibitor LOXO-435 [NCIt concept]
- FGFR3 Inhibitor TYRA-300 [NCIt concept]
- Gunagratinib [NCIt concept]
- Indium In 111 Vofatamab [NCIt concept]
- Infigratinib [NCIt concept]
- Masitinib Mesylate [NCIt concept]
- Resigratinib [NCIt concept]
- Rogaratinib [NCIt concept]
- Vofatamab [NCIt concept]

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