Preferred Label : FGFR3/4 Inhibitor TYRA-430;
NCIt synonyms : FGFR4/3 Inhibitor TYRA-430;
NCIt definition : An orally bioavailable reversible inhibitor of fibroblast growth factor receptor (FGFR)
types 3 and 4 (FGFR3/4), with potential antineoplastic activity. Upon oral administration,
FGFR3/4 inhibitor TYRA-430 targets, reversibly binds to and inhibits FGFR3/4. This
blocks the signaling through these receptors mediated by the ligand fibroblast growth
factor 19 (FGF19), thereby inhibiting tumor cell proliferation in FGF19- and FGFR4-overexpressing
tumor cells. FGFR, a family of receptor tyrosine kinases upregulated in many tumor
cell types, plays a key role in cellular proliferation, cell survival and angiogenesis.
FGF19 is overexpressed by certain tumor cell types.;
Molecule name : TYRA 430; TYRA-430;
Origin ID : C217027;
concept_is_in_subset
- has_target
