Preferred Label : FGFR3 Inhibitor TYRA-300;
NCIt definition : An orally bioavailable, selective inhibitor of human fibroblast growth factor receptor
3 (FGFR3), with potential antineoplastic activity. Upon oral administration, FGFR3
inhibitor TYRA-300 specifically targets and binds to certain FGFR3 activating gene
alterations, and specifically the gatekeeper mutants V555L/M. This blocks FGFR3-mediated
signaling and leads to an inhibition of tumor cell proliferation in FGFR3-overexpressing
cells. FGFR3, a receptor tyrosine kinase, is involved in angiogenesis and in the proliferation,
differentiation, and survival of tumor cells. FGFR3 expression is associated with
poor prognosis. It is overexpressed by certain tumor cell types.;
Molecule name : TYRA 300; TYRA-300;
NCI Metathesaurus CUI : CL1799355;
Origin ID : C190779;
UMLS CUI : C5783929;
Semantic type(s)
- concept_is_in_subset
- has_target
