Anti-FGFR3 Antibody-drug Conjugate LY3076226

Preferred Label : Anti-FGFR3 Antibody-drug Conjugate LY3076226;

NCIt synonyms : ADC LY3076226; Anti-fibroblast Growth Factor Receptor 3 Antibody-Drug Conjugate LY3076226; Anti-FGFR3 ADC LY3076226;

NCIt related terms : LY-3076226;

NCIt definition : An antibody-drug conjugate (ADC) composed of a human monoclonal antibody against the fibroblast growth factor receptor type 3 (FGFR3) that is conjugated to an undisclosed cytotoxic agent, with potential antineoplastic activity. Upon administration, the antibody moiety of anti-FGFR3 ADC LY3076226 binds to FGFR3. Upon internalization, the cytotoxic moiety causes cell death in FGFR3-expressing tumor cells. FGFR3, a receptor tyrosine kinase upregulated or mutated in many tumor cell types, plays a key role in tumor cell proliferation.;

UNII : GP2L3N7FIM;

Molecule name : LY3076226;

NCI Metathesaurus CUI : CL498222;

Details

Origin ID

C123829;

UMLS CUI

C4085972;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- LY3076226 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Fibroblast Growth Factor Receptor 3 [NCIt concept]

Keyword's position in hierarchy(ies) :

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