Preferred Label : FGFR1/2/3 Inhibitor TYRA-200;
NCIt synonyms : FGFR Inhibitor TYRA-200;
NCIt definition : An orally bioavailable inhibitor of the tyrosine kinase fibroblast growth factor receptor
(FGFR) types 1, 2, and 3 (FGFR1/2/3), with potential antineoplastic activity. Upon
oral administration, FGFR1/2/3 inhibitor TYRA-200 targets, binds to and inhibits FGFR1/2/3,
and is specifically active against certain FGFR2 fusions, molecular brake and gatekeeper
resistance mutations. This may result in the inhibition of FGFR1/2/3-related signal
transduction pathways. This inhibits proliferation in FGFR1/2/3-overexpressing tumor
cells. FGFR, a family of receptor tyrosine kinases (RTKs), is upregulated in many
tumor cell types.;
Molecule name : TYRA 200; TYRA-200;
Origin ID : C203336;
concept_is_in_subset
- has_target
