Fibroblast Growth Factor Receptor 1

Preferred Label : Fibroblast Growth Factor Receptor 1;

NCIt synonyms : FGFR1; bFGF-R-1; Proto-Oncogene c-Fgr; BFGFR; FMS-Like Tyrosine Kinase 2; N-sam; EC 2.7.10.1; Basic Fibroblast Growth Factor Receptor 1; Fibroblast Growth Factor Receptor-1; FLT-2; CD331 Antigen; FGFR-1;

NCIt definition : Fibroblast growth factor receptor 1 (822 aa, 92 kDa) is encoded by the human FGFR1 gene. This protein is involved in the regulation of embryonic development, cell proliferation, cell differentiation and cellular migration.;

NCIt note : At least 21 isoforms of the fibroblast growth factor receptor 1 protein have been described. They are the products of alternative splicing and exibihit tissue-specific patterns of expression.;

Details

Origin ID

C17590;

UMLS CUI

C1527757;

OMIM relation
- Fibroblast growth factor receptor 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- FGFR1 protein, human [MeSH concept]
- FGFR1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- FGFR1 Gene [NCIt concept]
- Fibroblast Growth Factor Receptor Family Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Growth Factor Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_gene_product_variant
- FGFR1 NP_075598.2:p.K656E [NCIt concept]
- FGFR1 Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Adherens Junction Assembly Pathway [NCIt concept]
- FGF Signaling Pathway [NCIt concept]
- Glypican 1 Signaling Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- Melanoma Pathway [NCIt concept]
- N-Cadherin Signaling Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
- Syndecan-4-Mediated Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Myeloproliferation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Dovitinib [NCIt concept]
- FGFR1/2/3 Inhibitor TYRA-200 [NCIt concept]
- Gunagratinib [NCIt concept]
- Infigratinib [NCIt concept]
- Orantinib [NCIt concept]
- Receptor Tyrosine Kinase Inhibitor R1530 [NCIt concept]
- Resigratinib [NCIt concept]
- Rogaratinib [NCIt concept]
- Sulfatinib [NCIt concept]

Keyword's position in hierarchy(ies) :

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