Sulfatinib - CISMeF

Preferred Label : Sulfatinib;

NCIt synonyms : Surufatinib;

NCIt definition : An orally bioavailable, small molecule inhibitor of vascular endothelial growth factor receptors (VEGFR) 1, 2, and 3, and the fibroblast growth factor receptor type 1 (FGFR1), with potential antineoplastic and anti-angiogenic activities. Upon oral administration, sulfatinib binds to and inhibits VEGFRs and FGFR1 thereby inhibiting VEGFR- and FGFR1-mediated signal transduction pathways. This leads to a reduction of angiogenesis and tumor cell proliferation in VEGFR/FGFR1-overexpressing tumor cells. Expression of VEGFRs and FGFR1 may be upregulated in a variety of tumor cell types.;

UNII : B2K5L1L8S9;

InChIKey : TTZSNFLLYPYKIL-UHFFFAOYSA-N;

CAS number : 1308672-74-3;

Molecule name : HMPL-012;

NCI Metathesaurus CUI : CL473485;

Details

Origin ID

C116066;

UMLS CUI

C3897426;

Automatic exact mappings (from CISMeF team)
- surufatinib [MeSH concept]
- surufatinib [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- surufatinib [MeSH Supplementary Concept]
- surufatinib [ATC Code]
Validated automatic mappings to BTNT
- surufatinib [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Fibroblast Growth Factor Receptor 1 [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 1 [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 2 [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 3 [NCIt concept]

Keyword's position in hierarchy(ies) :

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