Vascular Endothelial Growth Factor Receptor 1

Preferred Label : Vascular Endothelial Growth Factor Receptor 1;

NCIt synonyms : Tyrosine Protein Kinase FRT; VEGFR-1; Vascular Endothelial Growth Factor Receptor; Vascular Endothelial Growth Factor Receptor-1; Receptor Tyrosine Kinase,Class V; Tyrosine Protein Kinase Receptor FLT; FLT1; VEGFR; VEGFR1; FLT-1; Tyrosine-Protein Kinase Receptor FLT; Vascular Permeability Factor Receptor; Fms-Like Tyrosine Kinase 1; EC 2.7.10.1; Tyrosine-Protein Kinase FRT; FLT;

NCIt definition : Vascular endothelial growth factor receptor 1 (1338 aa, 151 kDa) is encoded by the human FLT1 gene. This protein is involved in angiogenesis, tyrosine phosphorylation, ligand binding and signal transduction.;

Details

Origin ID

C17975;

UMLS CUI

C1568520;

Currated CISMeF NLP mapping
- receptors, vascular endothelial growth factor [MeSH Descriptor]
- receptors, vascular endothelial growth factor [MeSH concept]
- vascular endothelial growth factor Receptor-1 [MeSH concept]
- vascular endothelial growth factor receptor-1 [MeSH Descriptor]
OMIM relation
- Fms-related tyrosine kinase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- FLT1 protein, human [MeSH concept]
- FLT1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- FLT1 Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Growth Factor Receptor [NCIt concept]
- Kinase [NCIt concept]
- Vascular Endothelial Growth Factor Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Angiogenesis Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Nitric Oxide Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Cabozantinib [NCIt concept]
- Cabozantinib S-malate [NCIt concept]
- Cediranib [NCIt concept]
- Cediranib Maleate [NCIt concept]
- Fruquintinib [NCIt concept]
- Glesatinib [NCIt concept]
- Icrucumab [NCIt concept]
- Pan HER/VEGFR2 Receptor Tyrosine Kinase Inhibitor BMS-690514 [NCIt concept]
- Receptor Tyrosine Kinase Inhibitor R1530 [NCIt concept]
- Sulfatinib [NCIt concept]
- Sunitinib [NCIt concept]
- Sunitinib Malate [NCIt concept]
- Tivozanib [NCIt concept]
- Tivozanib Hydrochloride [NCIt concept]
- VEGFR2/PDGFR/c-Kit/Flt-3 Inhibitor SU014813 [NCIt concept]
- Vatalanib [NCIt concept]
- Vatalanib Succinate [NCIt concept]

Keyword's position in hierarchy(ies) :

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