Preferred Label : Fruquintinib;
NCIt synonyms : VEGFR-1/2/3 Inhibitor HMPL-013; 6-(6,7-Dimethoxyquinazolin-4-yl)oxy-N,2-dimethyl-1-benzofuran-3-carboxamide;
NCIt definition : An orally available, small molecule inhibitor of vascular endothelial growth factor
receptors (VEGFRs), with potential anti-angiogenic and antineoplastic activities.
Upon oral administration, fruquintinib inhibits VEGF-induced phosphorylation of VEGFRs
1, 2, and 3 which may result in the inhibition of migration, proliferation and survival
of endothelial cells, microvessel formation, the inhibition of tumor cell proliferation,
and tumor cell death. Expression of VEGFRs may be upregulated in a variety of tumor
cell types.;
UNII : 49DXG3M5ZW;
InChIKey : BALLNEJQLSTPIO-UHFFFAOYSA-N;
CAS number : 1194506-26-7;
Drug name : Elunate; Fruzaqla;
Molecule name : HMPL-013; HMPL 013;
Codes from synonyms : 236;
Origin ID : C102852;
UMLS CUI : C3640966;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
