NCIt definition : An orally bioavailable, small-molecule, multitargeted tyrosine kinase inhibitor with
potential antineoplastic activity. Glesatinib binds to and inhibits the phosphorylation
of several receptor tyrosine kinases (RTKs), including the c-Met receptor (hepatocyte
growth factor receptor); the Tek/Tie-2 receptor; vascular endothelial growth factor
receptor (VEGFR) types 1, 2, and 3; and the macrophage-stimulating 1 receptor (MST1R
or RON). Inhibition of these RTKs and their downstream signaling pathways may result
in the inhibition of tumor angiogenesis and tumor cell proliferation in tumors overexpressing
these RTKs.;
UNII : 7Q29OXD98N;
InChIKey : YRCHYHRCBXNYNU-UHFFFAOYSA-N;
CAS number : 936694-12-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 936694-12-1
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