" /> Glesatinib - CISMeF





Preferred Label : Glesatinib;

NCIt synonyms : TKI MGCD265; Tyrosine Kinase Inhibitor MGCD265;

NCIt definition : An orally bioavailable, small-molecule, multitargeted tyrosine kinase inhibitor with potential antineoplastic activity. Glesatinib binds to and inhibits the phosphorylation of several receptor tyrosine kinases (RTKs), including the c-Met receptor (hepatocyte growth factor receptor); the Tek/Tie-2 receptor; vascular endothelial growth factor receptor (VEGFR) types 1, 2, and 3; and the macrophage-stimulating 1 receptor (MST1R or RON). Inhibition of these RTKs and their downstream signaling pathways may result in the inhibition of tumor angiogenesis and tumor cell proliferation in tumors overexpressing these RTKs.;

UNII : 7Q29OXD98N;

InChIKey : YRCHYHRCBXNYNU-UHFFFAOYSA-N;

CAS number : 936694-12-1;

Molecule name : MGCD265; MG90265; MG90265X;

NCI Metathesaurus CUI : CL383618;

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30/05/2025


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