Pan HER/VEGFR2 Receptor Tyrosine Kinase Inhibitor BMS-690514 - CISMeF
Pan HER/VEGFR2 Receptor Tyrosine Kinase Inhibitor BMS-690514NCIt concept
Preferred Label : Pan HER/VEGFR2 Receptor Tyrosine Kinase Inhibitor BMS-690514;
NCIt synonyms : Pan HER VEGFR2 Receptor Tyrosine Kinase Inhibitor BMS-690154;
NCIt related terms : BMS-690514;
NCIt definition : A pyrrolotriazine-based compound and a pan inhibitor of receptor tyrosine kinases
with potential antineoplastic activity. Pan HER/VEGFR2 receptor tyrosine kinase inhibitor
BMS-690514 binds to human epidermal growth factor receptors (EGFR) 1, 2 and 4 (HER1,
HER2 and HER4) and vascular endothelial growth factor receptor 1, 2 and 3 (VEGFR-1,
-2 and -3), all of which are frequently overexpressed by a variety of tumor types.
Binding of this agent to these receptors may result in the inhibition of tumor cell
proliferation; the inhibition of endothelial cell migration and proliferation and
angiogenesis; and tumor cell death.;
UNII : VKU5X213Q7;
CAS number : 859853-30-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 859853-30-8
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