Receptor Tyrosine-Protein Kinase ErbB-4

Preferred Label : Receptor Tyrosine-Protein Kinase ErbB-4;

NCIt synonyms : c-erbB-4; ERBB4 Receptor Protein Tyrosine Kinase; erbB4;

NCIt definition : Receptor tyrosine-protein kinase erbB-4 (1308 aa, 147 kDa) is encoded by the human ERBB4 gene. This protein is involved in multicellular organismal development, cell proliferation and signal transduction.;

NCIt note : ErbB4 heterodimerizes with other type I receptor tyrosine kinases. In the peripheral nervous system, ErbB4 helps regulate glial proliferation and acts as a signaling molecule at the neuromuscular junction. In the mature CNS, ErbB4 is expressed in cerebellar granule cells and in a subset of cells that also express the neurotransmitter: aminobutyric acid. ErbB4 is critical in cardiac development. It is overexpressed frequently in several common solid tumors, including in breast cancer.;

Details

Origin ID

C17685;

UMLS CUI

C3853568;

OMIM relation
- Erb-b2 receptor tyrosine kinase 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ERBB4 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Brain [NCIt concept]
- Heart [NCIt concept]
- Kidney [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_biomarker_type
- Tumor Marker [NCIt concept]
gene_product_is_element_in_pathway
- ERBB2 Signaling Pathway [NCIt concept]
- Gamma-Secretase Mediated ErbB4 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Growth Regulation [NCIt concept]
- Cell Proliferation [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Maturation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Canertinib Dihydrochloride [NCIt concept]
- Hypoxia-activated Prodrug TH-4000 [NCIt concept]
- Pan HER/VEGFR2 Receptor Tyrosine Kinase Inhibitor BMS-690514 [NCIt concept]
- Pan-HER Inhibitor FCN-411 [NCIt concept]
- pan-HER Kinase Inhibitor AC480 [NCIt concept]

Keyword's position in hierarchy(ies) :

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