Canertinib Dihydrochloride

Preferred Label : Canertinib Dihydrochloride;

NCIt related terms : canertinib; N-[-4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide Dihydrochloride; CI-1033;

NCIt definition : The hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities. Canertinib binds to the intracellular domains of epidermal growth factor receptor tyrosine kinases (ErbB family), irreversibly inhibiting their signal transduction functions and resulting in tumor cell apoptosis and suppression of tumor cell proliferation. This agent also acts as a radiosensitizing agent and displays synergistic activity with other chemotherapeutic agents.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer. Canertinib blocks the action of proteins called epidermal growth factor receptors, and may cause cancer cells to die. It is a type of tyrosine kinase inhibitor.;

UNII : ICJ93X8X90;

InChIKey : JZZFDCXSFTVOJY-UHFFFAOYSA-N;

CAS number : 289499-45-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 289499-45-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : PD183805; CI-1033; PD-0183805-002B;

Chemical formula : C24H25ClFN5O3.2HCl;

Codes from synonyms : 50460; CDR0000045040; CDR0000560928; CDR0000579644;

Details

Origin ID

C1880;

UMLS CUI

C1707132;

Currated CISMeF NLP mapping
- canertinib dihydrochloride [MeSH Supplementary Concept]
- canertinib dihydrochloride [MeSH concept]
See also inter- (CISMeF)
- canertinib [MeSH Supplementary Concept]
- canertinib [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- canertinib dihydrochloride [MeSH Supplementary Concept]
- canertinib dihydrochloride [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Canertinib [NCIt concept]
has_target
- Epidermal Growth Factor Receptor [NCIt concept]
- Receptor Tyrosine-Protein Kinase ErbB-4 [NCIt concept]
- Receptor Tyrosine-Protein Kinase erbB-2 [NCIt concept]
- Receptor Tyrosine-Protein Kinase erbB-3 [NCIt concept]
is_salt_form_of
- Canertinib [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients