Receptor Tyrosine-Protein Kinase erbB-3

Preferred Label : Receptor Tyrosine-Protein Kinase erbB-3;

NCIt synonyms : ERBB3 Protein; Tyrosine Kinase-Type Cell Surface Receptor HER3; c-erbB-3; ERBB3 Receptor Protein-Tyrosine Kinase; Receptor Tyrosine-Protein Kinase erbB3;

NCIt definition : Receptor tyrosine-protein kinase erbB3 (1342 aa, 148 kDa) is encoded by the human ERBB3 gene. This protein plays a role in protein amino acid phosphorylation.;

NCIt note : HER3/erbB3. Member of the EGF receptor (erbB) family. Receptor for NDF/heregulin (Neu differentiation factor); heterodimerizes with other type I receptor tyrosine kinases. It is overexpressed frequently in several common solid tumors, including in breast cancer.;

Details

Origin ID

C18490;

UMLS CUI

C3657415;

Automatic exact mappings (from CISMeF team)
- Erb-b2 receptor tyrosine kinase 3 [OMIM gene]
- receptor, erbb-3 [MeSH Descriptor]
OMIM relation
- Erb-b2 receptor tyrosine kinase 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- ERBB3 protein, human [MeSH concept]
- ERBB3 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ERBB3 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_biomarker_type
- Tumor Marker [NCIt concept]
gene_product_is_element_in_pathway
- ERBB2 Signaling Pathway [NCIt concept]
- ErbB3 Receptor Recycling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Growth Regulation [NCIt concept]
- Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Anti-EGFR/HER2/HER3 Monoclonal Antibody Mixture Sym013 [NCIt concept]
- Anti-EGFR/anti-HER3 Antibody-drug Conjugate BL-B01D1 [NCIt concept]
- Anti-ErbB2/Anti-ErbB3 Bispecific Monoclonal Antibody MM-111 [NCIt concept]
- Anti-ErbB3 Monoclonal Antibody AV-203 [NCIt concept]
- Anti-ErbB3 Monoclonal Antibody CDX-3379 [NCIt concept]
- Anti-HER3 Antibody-drug Conjugate SHR-A2009 [NCIt concept]
- Anti-HER3 Antibody-drug Conjugate YL202 [NCIt concept]
- Anti-HER3 Dendritic Cell Vaccine [NCIt concept]
- Anti-HER3 Monoclonal Antibody GSK2849330 [NCIt concept]
- Anti-HER3 Monoclonal Antibody SIBP-03 [NCIt concept]
- Anti-HER3/Topoisomerase I Inhibitor Antibody-drug Conjugate DB-1310 [NCIt concept]
- Canertinib Dihydrochloride [NCIt concept]
- Copper Cu 64-DOTA-Anti-HER3 Monoclonal Antibody U3-1287 [NCIt concept]
- Duligotuzumab [NCIt concept]
- Elgemtumab [NCIt concept]
- Hypoxia-activated Prodrug TH-4000 [NCIt concept]
- Istiratumab [NCIt concept]
- Izalontamab [NCIt concept]
- Nezutatug [NCIt concept]
- Pan-HER Inhibitor FCN-411 [NCIt concept]
- Patritumab [NCIt concept]
- Patritumab Deruxtecan [NCIt concept]
- Seribantumab [NCIt concept]
- Zenocutuzumab [NCIt concept]
- pan-HER Kinase Inhibitor AC480 [NCIt concept]

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