NCIt definition : A proprietary, hypoxia-activated prodrug with potential antineoplastic activity. Upon
administration, tarloxotinib is activated in the hypoxic cells within tumors into
an irreversible pan-HER inhibitor via a mechanism of action not yet fully elucidated.
As a result, this agent inhibits cellular proliferation and differentiation of tumor
cells overexpressing HER kinases, which belong to the epidermal growth factor receptor
(EGFR) family of receptor tyrosine kinases. Healthy, normal tissues may be spared
due to the hypoxia-specific activity of this agent, potentially reducing systemic
toxicity.;