Preferred Label : Hypoxia-activated Prodrug TH-4000;
NCIt definition : A proprietary, hypoxia-activated prodrug with potential antineoplastic activity. Upon
administration, the hypoxia-activated prodrug TH-4000 is activated in the hypoxic
cells within tumors into an irreversible pan-HER inhibitor via a mechanism of action
not yet fully elucidated. As a result, this agent inhibits cellular proliferation
and differentiation of tumor cells overexpressing HER kinases, which belong to the
epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. Healthy,
normal tissues may be spared due to the hypoxia-specific activity of this agent, potentially
reducing systemic toxicity.;
Drug name : Hypoxin;
Molecule name : PR610; TH-4000;
NCI Metathesaurus CUI : CL435780;
Origin ID : C101523;
UMLS CUI : C4053585;
Semantic type(s)
- concept_is_in_subset
- has_target
