" /> Vatalanib - CISMeF





Preferred Label : Vatalanib;

NCIt synonyms : N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine;

NCIt related terms : PTK787/ZK 222584;

NCIt definition : An orally bioavailable anilinophthalazine with potential antineoplastic activity. Vatalanib binds to and inhibits the protein kinase domain of vascular endothelial growth factor receptors 1 and 2; both receptor tyrosine kinases are involved in angiogenesis. This agent also binds to and inhibits related receptor tyrosine kinases, including platelet-derived growth factor (PDGF) receptor, c-Kit, and c-Fms.;

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called protein tyrosine kinase inhibitors and VEGF receptor kinase inhibitors.;

UNII : 5DX9U76296;

InChIKey : YCOYDOIWSSHVCK-UHFFFAOYSA-N;

CAS number : 212141-54-3;

Molecule name : ZK-232934; CGP-79787; PTK787; CGP 79787;

Chemical formula : C20H15ClN4;

NSC code : 719335;

Codes from synonyms : CDR0000046711; CDR0000390321;

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01/06/2025


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