vascular endothelial growth factor receptor-1

Preferred Label : vascular endothelial growth factor receptor-1;

MeSH definition : A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.;

MeSH synonym : flt vegf receptor; flt1 receptor tyrosine kinase; flt1 rtk; proto-oncogene protein flt; vegf receptor, flt; vegf receptor flt 1 protein; vegf receptor flt-1 protein; vegfr-1; proto oncogene protein flt; receptor, flt vegf; fms-like tyrosine kinase; tyrosine kinase, fms-like; vascular endothelial growth factor receptor 1;

CISMeF synonym : EC 2.7.1.112;

Registry Number MeSH : EC 2.7.10.1;

Is substance : O;

UNII : EC 2.7.10.1;

Details

Origin ID

D040281;

UMLS CUI

C0378516;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Vascular Endothelial Growth Factor Receptor 1 [NCIt concept]
Indexing information
- 1-(4-(1H-pyrazolo(3,4-d)pyrimidin-4-yloxy)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea [MeSH Supplementary Concept]
- 3-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one [MeSH Supplementary Concept]
Record concept(s)
- vascular endothelial growth factor Receptor-1 [MeSH concept]
Related MeSH Supplementary Concept(s)
- FLT1 protein, human [MeSH Supplementary Concept]
- FLT1 protein, zebrafish [MeSH Supplementary Concept]
- Flt(1-3)-IgG [MeSH Supplementary Concept]
- Flt1 protein, mouse [MeSH Supplementary Concept]
- Flt1 protein, rat [MeSH Supplementary Concept]
- HB-002.1 fusion protein [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Icrucumab [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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