Icrucumab - CISMeF

Preferred Label : Icrucumab;

NCIt synonyms : Anti-Vascular Endothelial Growth Factor Receptor-1 Monoclonal Antibody IMC-18F1; Anti-VEGFR-1 Monoclonal Antibody IMC-18F1;

NCIt definition : A fully human IgG1 monoclonal antibody directed against human vascular endothelial growth factor receptor 1 (VEGFR-1/FLT-1) with potential antiangiogenesis and antineoplastic activities. Icrucumab specifically binds to and inhibits the activity of VEGFR-1, which may prevent the activation of downstream signaling pathways and so inhibit tumor angiogenesis; the subsequent reduction in tumor nutrient supply may inhibit tumor cell proliferation. Tumor cell overexpression of VEGFR-1 may be associated with tumor angiogenesis and tumor cell proliferation and invasion; VEGFR-1 may modulate VEGFR-2 signaling.;

UNII : T7H0B1R64U;

CAS number : 1024603-92-6;

Molecule name : IMC-18F1;

Details

Origin ID

C79808;

UMLS CUI

C2698155;

Automatic exact mappings (from CISMeF team)
- Icrucumab [MeSH concept]
Currated CISMeF NLP mapping
- Icrucumab [MeSH Supplementary Concept]
See also inter- (CISMeF)
- FLT1 protein, human [MeSH Supplementary Concept]
- vascular endothelial growth factor receptor-1 [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Icrucumab [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Antibody-Dependent Cellular Cytotoxicity [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Vascular Endothelial Growth Factor Receptor 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients