Cediranib Maleate

Preferred Label : Cediranib Maleate;

NCIt synonyms : AZD2171 Maleate; Quinazoline, 4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-(3-(1-pyrrolidinyl)propoxy)-;

NCIt related terms : AZD2171; Recentin;

NCIt definition : The maleate salt of an indole ether quinazoline derivative with antineoplastic activities. Competing with adenosine triphosphate, cediranib binds to and inhibits all three vascular endothelial growth factor receptor (VEGFR-1,-2,-3) tyrosine kinases, thereby blocking VEGF-signaling, angiogenesis, and tumor cell growth.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer. Cediranib maleate may prevent the growth of new blood vessels that tumors need to grow and may kill cancer cells. It is a type of antiangiogenesis agent and a type of vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor.;

UNII : 68AYS9A614;

InChIKey : JRMGHBVACUJCRP-BTJKTKAUSA-N;

CAS number : 857036-77-2;

Drug name : Recentin;

Chemical formula : C25H27FN4O3.C4H4O4;

NSC code : 732208;

Codes from synonyms : CDR0000597183; CDR0000597182; CDR0000430872;

Details

Origin ID

C48379;

UMLS CUI

C2711999;

Automatic exact mappings (from CISMeF team)
- AZD2171 [MeSH concept]
Currated CISMeF NLP mapping
- cediranib maleate [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- cediranib [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- Vascular Endothelial Growth Factor Receptor [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Receptor Tyrosine Kinase Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Negative Regulation of Angiogenesis [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Cediranib [NCIt concept]
has_target
- Receptor-Type Tyrosine-Protein Kinase FLT3 [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 1 [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 2 [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 3 [NCIt concept]
is_salt_form_of
- Cediranib [NCIt concept]

Keyword's position in hierarchy(ies) :

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