Cediranib - CISMeF

Preferred Label : Cediranib;

NCIt synonyms : 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline;

NCIt definition : An orally bioavailable indole ether quinazoline derivative and vascular endothelial growth factor receptor (VEGFR) inhibitor, with potential antineoplastic activity. Upon oral administration, cediranib binds to and inhibits the three VEGFR subtypes 1 (VEGFR-1), 2 (VEGFR-2) and 3 (VEGFR-3), thereby blocking VEGF-signaling, angiogenesis, and tumor cell growth. Expression of VEGFRs may be upregulated in a variety of tumor cell types.;

UNII : NQU9IPY4K9;

InChIKey : XXJWYDDUDKYVKI-UHFFFAOYSA-N;

CAS number : 288383-20-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 288383-20-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : AZ-D2171;

Chemical formula : C25H27FN4O3;

Codes from synonyms : 94;

Details

Origin ID

C80867;

UMLS CUI

C1698364;

Automatic exact mappings (from CISMeF team)
- Cediranib [ICD-11 Extension code]
- cediranib [ATC Code]
Currated CISMeF NLP mapping
- cediranib [MeSH Supplementary Concept]
- cediranib [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- cediranib [ATC Code]
- cediranib [MeSH Supplementary Concept]
- cediranib [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Cediranib Maleate [NCIt concept]
has_target
- Vascular Endothelial Growth Factor Receptor 1 [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 2 [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 3 [NCIt concept]
is_free_acid_or_base_form_of
- Cediranib Maleate [NCIt concept]

Keyword's position in hierarchy(ies) :

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