Tivozanib Hydrochloride

Preferred Label : Tivozanib Hydrochloride;

NCIt synonyms : Tivozanib Monohydrochloride Monohydrate; Tivozanib Hydrochloride Hydrate;

NCIt definition : The hydrochloride salt of tivozanib, an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis.;

UNII : 8A9H4VK35Z;

InChIKey : RQXMKRRBJITKRN-UHFFFAOYSA-N;

CAS number : 682745-41-1;

Drug name : Fotivda;

NCI Metathesaurus CUI : CL553998;

Détails

Origin ID

C152666;

UMLS CUI

C4765027;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Tivozanib hydrochloride (substance) [SNOMED CT concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Tivozanib [NCIt concept]
has_target
- Vascular Endothelial Growth Factor Receptor 1 [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 2 [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 3 [NCIt concept]
is_component_of_chemotherapy_regimen
- Tivozanib Regimen [NCIt concept]
is_salt_form_of
- Tivozanib [NCIt concept]

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