NCIt definition : The hydrochloride salt of tivozanib, an orally bioavailable inhibitor of vascular
endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic
and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3,
which may result in the inhibition of endothelial cell migration and proliferation,
inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently
overexpressed by a variety of tumor cell types, play a key role in angiogenesis.;
UNII : 8A9H4VK35Z;
InChIKey : RQXMKRRBJITKRN-UHFFFAOYSA-N;
CAS number : 682745-41-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 682745-41-1
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