Tivozanib - CISMeF

Preferred Label : Tivozanib;

NCIt synonyms : Urea, N-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)-;

NCIt definition : An orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis.;

UNII : 172030934T;

InChIKey : SPMVMDHWKHCIDT-UHFFFAOYSA-N;

CAS number : 475108-18-0;

Molecule name : AV-951; AV 951;

Chemical formula : C22H19ClN4O5;

Codes from synonyms : 500;

Details

Origin ID

C85444;

UMLS CUI

C2827667;

Automatic exact mappings (from CISMeF team)
- Tivozanib [ICD-11 Extension code]
- tivozanib [ATC Code]
Currated CISMeF NLP mapping
- Tivozanib (substance) [SNOMED CT concept]
- tivozanib [MeSH concept]
- tivozanib [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing tivozanib (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing tivozanib (medicinal product) [SNOMED CT concept]
- Tivozanib (substance) [SNOMED CT concept]
- tivozanib [MeSH Supplementary Concept]
- tivozanib [MeSH concept]
- tivozanib [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Receptor Tyrosine Kinase Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Tivozanib Hydrochloride [NCIt concept]
has_target
- Vascular Endothelial Growth Factor Receptor 1 [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 2 [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 3 [NCIt concept]
is_free_acid_or_base_form_of
- Tivozanib Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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