NCIt definition : An orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs)
1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib
binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial
cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell
death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell
types, play a key role in angiogenesis.;
UNII : 172030934T;
InChIKey : SPMVMDHWKHCIDT-UHFFFAOYSA-N;
CAS number : 475108-18-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 475108-18-0
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