Viral Myocarditis Pathway

Preferred Label : Viral Myocarditis Pathway;

NCIt related terms : Viral myocarditis;

Alternative definition : KEGG: Myocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is still considered the dominant etiological agent. Myocarditis may be caused by direct cytopathic effects of virus, a pathologic immune response to persistent virus, or autoimmunity triggered by the viral infection. The virus enters the myocyte through internalization of the coxsackie-adenoviral receptor (CAR) and its coreceptor, decay-accelerating factor (DAF). Viral proteases cleave various proteins in the host cell. One example is viral protease 2A, which cleaves eukaryote initiation factor 4G (eIF4G) and the dystrophin protein, resulting in a complete shutdown of cap-dependent RNA translation and cytoskeletal destruction in infected cardiomyocytes, respectively. CVB3 also cleaves the member of the Bcl-2 family Bid, leading to apoptosis. CVB3 infection also induces the cleavage of cyclin D protein through a proteasome-dependent pathway, leading to the host cell-growth arrest. Viral infection and necrosis of myocytes may lead to the release of intracellular antigens, resulting in activation of self-reactive T cells. CVB infection is a significant cause of dilated cardiomyopathy (DCM) as well as myocarditis. Epidemiologically, myocarditis underlies a significant portion of patients with DCM.;

KEGG ID : hsa05416;

Details

Origin ID

C91441;

UMLS CUI

C2984254;

Automatic exact mappings (from CISMeF team)
- Viral myocarditis [MedDRA Preferred Term]
- Viral myocarditis [ICD-11 More detail]
- Viral myocarditis (disorder) [SNOMED CT concept]
Semantic type(s)
- Conceptual Entity [UMLS semantic type]
has_gene_product_element
- Activated Caspase-9 [NCIt concept]
- Alpha-1-Syntrophin [NCIt concept]
- Alpha-Sarcoglycan [NCIt concept]
- BH3-Interacting Domain Death Agonist [NCIt concept]
- Beta-Sarcoglycan [NCIt concept]
- CD40 Ligand [NCIt concept]
- Caspase-3 [NCIt concept]
- Caspase-8 [NCIt concept]
- Caspase-9 [NCIt concept]
- Caveolin-1 [NCIt concept]
- Complement Decay-Accelerating Factor [NCIt concept]
- Coxsackievirus and Adenovirus Receptor [NCIt concept]
- Cytochrome C [NCIt concept]
- Epsilon-Sarcoglycan [NCIt concept]
- HLA Class I Histocompatibility Antigen, Alpha Chain E [NCIt concept]
- HLA Class I Histocompatibility Antigen, Alpha Chain F [NCIt concept]
- HLA Class I Histocompatibility Antigen, Alpha Chain G [NCIt concept]
- HLA Class II Histocompatibility Antigen, DM Alpha Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DM Beta Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DO Beta Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DQ Alpha 1 Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DQ Beta 1 Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DR Alpha Chain [NCIt concept]
- Integrin Alpha-L [NCIt concept]
- Integrin Beta-2 [NCIt concept]
- Intercellular Adhesion Molecule 1 [NCIt concept]
- Laminin Subunit Alpha-2 [NCIt concept]
- Myosin-1 [NCIt concept]
- Myosin-2 [NCIt concept]
- Myosin-6 [NCIt concept]
- Myosin-9 [NCIt concept]
- Perforin-1 [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 1 [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 2 [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 3 [NCIt concept]
- T-Cell-Specific Surface Glycoprotein CD28 [NCIt concept]
- T-Lymphocyte Activation Antigen CD80 [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 5 [NCIt concept]
- Tyrosine-Protein Kinase ABL1 [NCIt concept]
- Tyrosine-Protein Kinase ABL2 [NCIt concept]
pathway_has_gene_element
- ABL1 wt Allele [NCIt concept]
- ABL2 wt Allele [NCIt concept]
- ACTG1 wt Allele [NCIt concept]
- BID wt Allele [NCIt concept]
- CASP3 wt Allele [NCIt concept]
- CASP8 wt Allele [NCIt concept]
- CASP9 wt Allele [NCIt concept]
- CAV1 wt Allele [NCIt concept]
- CD28 wt Allele [NCIt concept]
- CD40 wt Allele [NCIt concept]
- CD40LG wt Allele [NCIt concept]
- CD55 wt Allele [NCIt concept]
- CD80 wt Allele [NCIt concept]
- CXADR wt Allele [NCIt concept]
- CYCS wt Allele [NCIt concept]
- HLA-DMA wt Allele [NCIt concept]
- HLA-DMB wt Allele [NCIt concept]
- HLA-DOB wt Allele [NCIt concept]
- HLA-DQA1 wt Allele [NCIt concept]
- HLA-DQB1 wt Allele [NCIt concept]
- HLA-DRA wt Allele [NCIt concept]
- HLA-E wt Allele [NCIt concept]
- HLA-F wt Allele [NCIt concept]
- HLA-G wt Allele [NCIt concept]
- ICAM1 wt Allele [NCIt concept]
- ITGAL wt Allele [NCIt concept]
- ITGB2 wt Allele [NCIt concept]
- LAMA2 wt Allele [NCIt concept]
- MYH1 wt Allele [NCIt concept]
- MYH2 wt Allele [NCIt concept]
- MYH6 wt Allele [NCIt concept]
- MYH9 wt Allele [NCIt concept]
- PRF1 wt Allele [NCIt concept]
- RAC1 wt Allele [NCIt concept]
- RAC2 wt Allele [NCIt concept]
- RAC3 wt Allele [NCIt concept]
- SGCA wt Allele [NCIt concept]
- SGCB wt Allele [NCIt concept]
- SGCE wt Allele [NCIt concept]
- SNTA1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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