Tyrosine-Protein Kinase ABL2

Preferred Label : Tyrosine-Protein Kinase ABL2;

NCIt synonyms : ARG Tyrosine Kinase; ABL2 Tyrosine-Protein Kinase; ABL2; Abelson Murine Leukemia Viral Oncogene Homolog 2; ABL2 Tyrosine Kinase; Abelson-Related Gene Protein; EC 2.7.10.2; Tyrosine-Protein Kinase ARG; Abelson Tyrosine-Protein Kinase 2;

NCIt definition : Tyrosine-protein kinase ABL2 (1182 aa, 128 kDa) is encoded by the human ABL2 gene. This protein plays a role in cell motility, apoptosis, cell adhesion, receptor endocytosis, autophagy, tyrosine phosphorylation and signal transduction.;

NCIt note : 2 isoforms produced by alternate splicing;

Details

Origin ID

C18533;

UMLS CUI

C3853712;

Currated CISMeF NLP mapping
- ARG tyrosine kinase [MeSH concept]
- ARG tyrosine kinase [MeSH Supplementary Concept]
OMIM relation
- Abl protooncogene 2, nonreceptor tyrosine kinase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ABL2 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- SH2 Domain [NCIt concept]
- SH3 Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Branching Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- Viral Myocarditis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Therapeutic Breast/Ovarian/Prostate Peptide Cancer Vaccine DPX-0907 [NCIt concept]

Keyword's position in hierarchy(ies) :

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