NCIt synonyms : DQ-A1; Major Histocompatibility Complex, Class II, DQ Alpha 1 wt Allele; HLA-DQA; CD; FLJ27088; CELIAC1; FLJ27328; GSE; HLA DQA1;
NCIt definition : Human HLA-DQA1 wild-type allele is located in the vicinity of 6p21.3 and is approximately
6 kb in length. This allele, which encodes HLA class II histocompatibility antigen,
DQ alpha chain protein, plays a role in antigen presentation and the regulation of
the immune response. The gene is polymorphic and typing is often performed to determine
histocompatibility for hematopoietic stem cell transplantation.;
NCIt note : The HLA-DQA1 gene is expressed as multiple isoforms that dimerize with HLA-DQ beta
chain proteins to form HLA-DQ antigens.;