HLA Class I Histocompatibility Antigen, Alpha Chain E

Preferred Label : HLA Class I Histocompatibility Antigen, Alpha Chain E;

NCIt synonyms : HLA-E; MHC Class I Antigen E; HLAE;

NCIt definition : HLA class I histocompatibility antigen, alpha chain E (358 aa, 40 kDa) is encoded by the human HLA-E gene. This protein is involved in binding to nonameric peptides derived from the signal sequences of MHC class Ia molecules and the modulation of the cytotoxic activity of natural killer cells.;

NCI Metathesaurus CUI : CL1662402;

Details

Origin ID

C179684;

UMLS CUI

C0062887;

OMIM relation
- Major histocompatibility complex, class I, e [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- HLA-E Antigens [MeSH concept]
- HLA-E Antigens [MeSH Descriptor]
- HLA-E antigen [MeSH Supplementary Concept]
concept_is_in_subset
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- HLA-E Gene [NCIt concept]
- Immunoprotein Gene [NCIt concept]
- MHC Class I Gene [NCIt concept]
gene_product_expressed_in_tissue
- CD8-Positive T-Lymphocyte [NCIt concept]
gene_product_has_chemical_classification
- HLA Complex [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Allograft Rejection Pathway [NCIt concept]
- Antigen Processing and Presentation Pathway [NCIt concept]
- Autoimmune Thyroid Disease Pathway [NCIt concept]
- Cell Adhesion Molecule Signaling Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- Graft-Versus-Host Disease Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Phagocytosis Pathway [NCIt concept]
- Type I Diabetes Mellitus Pathway [NCIt concept]
- Viral Myocarditis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Antigen Presentation [NCIt concept]
- Cell-Mediated Cytotoxicity [NCIt concept]
- Immune System Process [NCIt concept]
- Immunologic Tolerance [NCIt concept]
- Immunoregulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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