Activated Caspase-9

Preferred Label : Activated Caspase-9;

NCIt synonyms : Activated CASP9; EC 3.4.22.62; Activated CASP-9; Activated Caspase 9;

NCIt definition : Activated caspase-9 ( 400 aa, 45 kDa) is encoded by the human CASP9 gene. This protein is involved in the induction of caspase-dependent apoptosis.;

NCIt note : Activated caspase-9 is a heterodimer formed by a 35 kDa (p35) and a 10 kDa (p10) subunit. The p35 and p10 subunits are produced by apoptotic protease-activating factor 1 (APAF1)-mediated proteolysis of caspase-9 (procaspase-9). APAF1 proteolysis removes the amino acids 316 through 330 of procaspase-9. Two heterodimers form an anti-parallel complex to obtain full enzymatic activity. (UniProt);

NCI Metathesaurus CUI : CL512851;

Details

Origin ID

C129925;

UMLS CUI

C4320087;

Automatic exact mappings (from CISMeF team)
- obsolete caspase-9 activity [GO term]
OMIM relation
- Caspase 9, apoptosis-related cysteine protease [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CASP9 Gene [NCIt concept]
- Caspase Gene [NCIt concept]
- Cysteine Peptidase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- AKT Signaling Pathway [NCIt concept]
- Alzheimer's Disease Pathway KEGG [NCIt concept]
- Amyotrophic Lateral Sclerosis Pathway [NCIt concept]
- Apoptosis DNA Damage Pathway [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- Caspase Cascade Pathway [NCIt concept]
- Caspase Cascade in Apoptosis [NCIt concept]
- D4-GDI Signaling Pathway [NCIt concept]
- DR3 and DR4/5 Mediated Apoptosis Pathway [NCIt concept]
- Endometrial Cancer Pathway [NCIt concept]
- HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha [NCIt concept]
- HIV-I Nef in Apoptosis Pathway [NCIt concept]
- HSP27 Regulation Pathway [NCIt concept]
- Huntington's Disease Pathway [NCIt concept]
- Mitochondria in Apoptotic Signaling Pathway [NCIt concept]
- Mucosal Healing Pathway [NCIt concept]
- Nerve Growth Factor Receptor Signaling Pathway [NCIt concept]
- Non-Small Cell Lung Cancer Pathway [NCIt concept]
- PI3K/AKT1 Signaling Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- Parkinson's Disease Pathway KEGG [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
- Ras Signaling Pathway [NCIt concept]
- Small Cell Lung Cancer Pathway [NCIt concept]
- VEGF Signaling Pathway [NCIt concept]
- Viral Myocarditis Pathway [NCIt concept]
- West Nile Virus Pathway [NCIt concept]
- p53 Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Caspase Activation [NCIt concept]
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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