Preferred Label : Caspase Gene;
NCIt definition : These genes encode caspases, a family of intracellular cysteine proteinases involved
in inflammation and apoptosis. These enzymes appear to be involved in the initial
signaling events, as well as the downstream proteolytic cleavages, that result in
apoptotic cell death. They are specific for aspartic acid at the P1 position and are
divided into two classes based on the lengths of their N-terminal pro-domains. Caspases-1,
-2, -4, -5, -8, and -10 have long pro-domains while caspases-3, -6, -7, and -9 have
short pro-domains. (from Science 1998. 281:1312 and Br Med Bull 1997. 53:478);
Origin ID : C26552;
UMLS CUI : C1332858;
Semantic type(s)
- gene_encodes_gene_product
- gene_found_in_organism
- gene_plays_role_in_process
