Caspase-5 - CISMeF

Preferred Label : Caspase-5;

NCIt synonyms : CASP5; CASP5 Protein; TY Protease; ICH-3 Protease; ICE(rel)-III; ICH3; Cysteine Protease; Caspase 5, Apoptosis-Related Cysteine Protease; Protease ICH-3; EC 3.4.22.58; CASP-5; Protease TY;

NCIt definition : Caspase-5 (434 aa, 50 kDa) is encoded by the human CASP5 gene. This protein is involved in both apoptosis and proteolysis.;

NCIt note : Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme.;

Details

Origin ID

C28434;

UMLS CUI

C0769345;

OMIM relation
- Caspase 5, apoptosis-related cysteine protease [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
Validated automatic mappings to NTBT
- cysteine proteases [MeSH concept]
- cysteine proteases [MeSH Descriptor]
gene_encodes_gene_product
- CASP5 Gene [NCIt concept]
- Caspase Gene [NCIt concept]
- Cysteine Peptidase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Liver [NCIt concept]
- Lung [NCIt concept]
- Skeletal Muscle Tissue [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- NOD-Like Receptor Signaling Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- T Acute Lymphoblastic Leukemia [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Hydrolysis [NCIt concept]
- Inflammatory Response [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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