Caspase-1 - CISMeF

Preferred Label : Caspase-1;

NCIt synonyms : CASP-1; Caspase 1, Apoptosis-Related Cysteine Protease (Interleukin 1, Beta, Convertase); Interleukin-1 Beta Converting Enzyme; IL1BC; Interleukin 1-Beta Convertase; IL1BCE; Interleukin 1-B Converting Enzyme; IL-1 Beta Converting Enzyme; EC 3.4.22.36; IL1B-Convertase; IL-1BC; CASP1; IL-1b Converting Enzyme; ICE; P45; Caspase 1, Apoptosis-Related Cysteine Protease;

NCIt definition : Caspase-1 (404 aa, 45 kDa) is encoded by the human CASP1 gene. This protein is involved in proteolysis and immunity.;

NCIt note : Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme.;

Details

Origin ID

C18045;

UMLS CUI

C4721557;

Currated CISMeF NLP mapping
- caspase 1 [MeSH Descriptor]
- caspase 1 [MeSH concept]
False automatic mappings
- Caspase-1 (substance) [SNOMED CT concept]
OMIM relation
- Caspase 1, apoptosis-related cysteine protease [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Caspase-1 (substance) [SNOMED CT concept]
- caspase 1 [MeSH Descriptor]
- caspase 1 [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CASP1 Gene [NCIt concept]
- Caspase Gene [NCIt concept]
- Cysteine Peptidase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Amyotrophic Lateral Sclerosis Pathway [NCIt concept]
- Caspase Cascade Pathway [NCIt concept]
- Caspase Cascade in Apoptosis [NCIt concept]
- Cellular Anthrax Toxin Pathway [NCIt concept]
- Cytosolic DNA-Sensing Pathway [NCIt concept]
- D4-GDI Signaling Pathway [NCIt concept]
- IL18 Signaling Pathway [NCIt concept]
- Interferon-Gamma Signaling Pathway [NCIt concept]
- NOD-Like Receptor Signaling Pathway [NCIt concept]
- Salmonella Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Hydrolysis [NCIt concept]
- Inflammatory Response [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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