Caspase-4 - CISMeF

Preferred Label : Caspase-4;

NCIt synonyms : Caspase 4, Apoptosis-Related Cysteine Protease; CASP4 Protein; ICH-2; ICE(rel)II; CASP4; ICErel-II; CASP-4; Apoptotic Cysteine Protease Mih1/TX; TX; EC 3.4.22.-; TX Protease; Mih1/TX; EC 3.4.22.57; Protease ICH-2; Protease TX;

NCIt definition : Caspase-4 (377 aa, 43 kDa) is encoded by the human CASP4 gene. This protein plays a role in both proteolysis and apoptosis.;

NCIt note : Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme.; Caspase-4 is able to cleave and activate its own, as well as caspase 1, precursor proteins. (UniProt);

Details

Origin ID

C28431;

UMLS CUI

C1437927;

Currated CISMeF NLP mapping
- CASP4 protein, human [MeSH concept]
- CASP4 protein, human [MeSH Supplementary Concept]
OMIM relation
- Caspase 4, apoptosis-related cysteine protease [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CASP4 protein, human [MeSH concept]
- CASP4 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CASP4 Gene [NCIt concept]
- Caspase Gene [NCIt concept]
- Cysteine Peptidase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Heart [NCIt concept]
- Kidney [NCIt concept]
- Liver [NCIt concept]
- Lung [NCIt concept]
- Skeletal Muscle Tissue [NCIt concept]
- Spleen [NCIt concept]
- Testis [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Caspase Cascade Pathway [NCIt concept]
- Caspase Cascade in Apoptosis [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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