" /> Activated Caspase-3 - CISMeF





Preferred Label : Activated Caspase-3;

NCIt synonyms : Activated CASP-3; Activated Caspase 3; Activated CASP3; Cleaved Caspase 3; Cleaved Caspase-3; Cleaved CASP-3; Cleaved CASP3;

NCIt definition : Activated caspase-3 (249 aa, 29 kDa) is encoded by the human CASP3 gene. This protein plays a role in the promotion of apoptosis.;

NCIt note : Denitrosylation of the active site thiol of caspase-3 is induced by the Fas-dependent apoptotic pathway and can also stimulate autocatalytic activity. (UniProt); Cleavage of caspase-3 by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits p17 and p12. Additional processing of caspase-3 propeptides is likely due to the autocatalytic activity of the activated protease. (UniProt); Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 and vice versa, also occur. (UniProt);

NCI Metathesaurus CUI : CL508660;

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Keyword's position in hierarchy(ies) : arborescence

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29/04/2024


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