Caspase-2 - CISMeF

Preferred Label : Caspase-2;

NCIt synonyms : Caspase 2, Apoptosis-Related Cysteine Protease (Neural Precursor Cell Expressed, Developmentally Down-Regulated 2); NEDD2 Apoptosis Regulatory Protein; NEDD2; Protein Phosphatase 1, Regulatory Subunit 57; Caspase 2, Apoptosis-Related Cysteine Protease; ICH-1L/1S; ICH-1; ICH-1 Protease; CASP-2; ICH-1L; Neural Precursor Cell Expressed, Developmentally Downregulated 2; CASP2; ICH1; EC 3.4.22.55; Protease ICH-1; Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 2;

NCIt definition : Caspase-2 (452 aa, 51 kDa) is encoded by the human CASP2 gene. This protein is involved in cell cycle arrest, apoptosis and proteolysis.;

NCIt note : Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme.;

Details

Origin ID

C20145;

UMLS CUI

C1453171;

OMIM relation
- Caspase 2, apoptosis-related cysteine protease [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CASP2 protein, human [MeSH Supplementary Concept]
- CASP2 protein, human [MeSH concept]
Validated automatic mappings to BTNT
- CASP2 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CASP2 Gene [NCIt concept]
- Caspase Gene [NCIt concept]
- Cysteine Peptidase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Brain [NCIt concept]
- Fetus [NCIt concept]
- Liver [NCIt concept]
- Skeletal Muscle Tissue [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Caspase Cascade Pathway [NCIt concept]
- Caspase Cascade in Apoptosis [NCIt concept]
- HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha [NCIt concept]
- HIV-I Nef in Apoptosis Pathway [NCIt concept]
- TNF Stress Related Signaling Pathway [NCIt concept]
- TNFR1 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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