Caspase-10 - CISMeF

Preferred Label : Caspase-10;

NCIt synonyms : FAS-Associated Death Domain Protein Interleukin-1B-Converting Enzyme 2; Apoptotic Protease MCH-4; FADD-Like ICE2; FLICE-2; CASP10; MCH4; CASP10 Protein; Interleukin-1B-Converting Enzyme 2; ICE-Like Apoptotic Protease 4; CASP-10; FLICE2; EC 3.4.22.63;

NCIt definition : Caspase-10 (521 aa, 59 kDa) is encoded by the human CASP10 gene. This protein plays a role in proteolysis, apoptosis induction and immunity.;

NCIt note : Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme.; Caspase-10 cleaves and activates caspases-3, -4, -6, -7, -8, and -9. (UniProt);

Details

Origin ID

C18287;

UMLS CUI

C1667078;

Automatic exact mappings (from CISMeF team)
- Autoimmune lymphoproliferative syndrome, type iia [OMIM Phenotype]
- Caspase 10, apoptosis-related cysteine protease [OMIM gene]
- Fas associated via death domain [ORDO Gene]
- Fas-Associated death domain protein [MeSH Descriptor]
- Fas-Associated death domain protein [MeSH concept]
- VSCYSPR1 protein, vicia sativa [MeSH Supplementary Concept]
- VSCYSPR2 protein, vicia sativa [MeSH Supplementary Concept]
- War5.2 protein, triticum aestivum [MeSH Supplementary Concept]
- XCL-2 calpain [MeSH Supplementary Concept]
- alg13 protein, zebrafish [MeSH Supplementary Concept]
- caspase 10 [ORDO Gene]
- caspase 10 [HGNC gene]
- cysteine proteases [MeSH Descriptor]
- cysteine proteases [MeSH concept]
- extra spindle pole bodies like 1, separase [HGNC gene]
- interleukin 1beta-converting enzyme 2 [MeSH Supplementary Concept]
- vacuolar processing enzyme beta, arabidopsis [MeSH Supplementary Concept]
- vacuolar processing enzyme gamma, arabidopsis [MeSH Supplementary Concept]
- vetch protease B [MeSH Supplementary Concept]
- vignain [MeSH Supplementary Concept]
- vinckepain 2, plasmodium falciparum [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- caspase 10 [MeSH Descriptor]
- caspase 10 [MeSH concept]
OMIM relation
- Caspase 10, apoptosis-related cysteine protease [OMIM gene]
See also inter- (CISMeF)
- Fas-Associated death domain protein [MeSH Descriptor]
- Fas-Associated death domain protein [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CASP10 protein, human [MeSH concept]
- CASP10 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CASP10 Gene [NCIt concept]
- Caspase Gene [NCIt concept]
- Cysteine Peptidase Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Apoptosis Pathway [NCIt concept]
- Caspase Cascade Pathway [NCIt concept]
- Caspase Cascade in Apoptosis [NCIt concept]
- D4-GDI Signaling Pathway [NCIt concept]
- DR3 and DR4/5 Mediated Apoptosis Pathway [NCIt concept]
- FAS Signaling Pathway PID [NCIt concept]
- Fas Signaling Pathway BioCarta [NCIt concept]
- RIG-I-Like Receptor Signaling Pathway [NCIt concept]
- TRAIL Signaling Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Non-Hodgkin Lymphoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Caspase Activation [NCIt concept]
- Hydrolysis [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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