D4-GDI Signaling Pathway

Preferred Label : D4-GDI Signaling Pathway;

Alternative definition : BIOCARTA: D4-GDP dissociation inhibitor (D4-GDI) is a negative regulator of the ras related Rho Family of GTPases. Since the rho GTPases promote cytoskeletal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block through its cleavage is important for inducing apoptosis. Caspase-3 cleaves the 28 kDa mature form of D4-GDI to give a 5 kDa and 23 kDa size fragment. The 23 kDa fragment then translocates to the nucleus. The mechanisms involving cleavage of D4-GDI with apoptosis are not presently known. Activation of the Jun N-Terminal kinase, a regulator of apoptosis, may be one of the mechanisms. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_d4gdiPathway;

Details

Origin ID

C39045;

UMLS CUI

C1511643;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Activated Caspase-9 [NCIt concept]
- Apoptotic Protease-Activating Factor 1 [NCIt concept]
- Caspase-1 [NCIt concept]
- Caspase-10 [NCIt concept]
- Caspase-3 [NCIt concept]
- Caspase-8 [NCIt concept]
- Caspase-9 [NCIt concept]
- Perforin-1 [NCIt concept]
- Rho GTPase-Activating Protein 5 [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
pathway_has_gene_element
- APAF1 wt Allele [NCIt concept]
- ARHGAP5 wt Allele [NCIt concept]
- CASP1 wt Allele [NCIt concept]
- CASP10 wt Allele [NCIt concept]
- CASP3 wt Allele [NCIt concept]
- CASP8 wt Allele [NCIt concept]
- CASP9 wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- PRF1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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